{"id":5979,"date":"2021-06-25T08:07:58","date_gmt":"2021-06-25T01:07:58","guid":{"rendered":"https:\/\/cdcangiang.vn\/?p=5979"},"modified":"2021-06-25T08:07:58","modified_gmt":"2021-06-25T01:07:58","slug":"chuyen-gia-ly-giai-ve-tinh-sinh-mien-dich-va-hieu-qua-bao-ve-cua-vac-xin-covid-19","status":"publish","type":"post","link":"https:\/\/cdcangiang.vn\/index.php\/2021\/06\/25\/chuyen-gia-ly-giai-ve-tinh-sinh-mien-dich-va-hieu-qua-bao-ve-cua-vac-xin-covid-19\/","title":{"rendered":"Chuy\u00ean gia l\u00fd gi\u1ea3i v\u1ec1 t\u00ednh sinh mi\u1ec5n d\u1ecbch v\u00e0 hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7 c\u1ee7a v\u1eafc xin COVID-19"},"content":{"rendered":"

Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p m\u1ed9t v\u1eafc xin c\u00f3 \u201ct\u00ednh sinh mi\u1ec5n d\u1ecbch\u201d ch\u01b0a ch\u1eafc \u0111\u00e3 c\u00f3 \u201chi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7\u201d. V\u00ec v\u1eady c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng th\u1eed nghi\u1ec7m v\u1eafc xin th\u01b0\u1eddng b\u1eaft bu\u1ed9c ph\u1ea3i \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7.<\/h2>\n
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V\u1edbi v\u1eafc xin COVID-19, t\u1ea1i th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i T\u1ed5 ch\u1ee9c Y t\u1ebf th\u1ebf gi\u1edbi y\u00eau c\u1ea7u ph\u1ea3i \u0111\u00e1nh gi\u00e1 c\u1ea3 \u201ct\u00ednh sinh mi\u1ec5n d\u1ecbch\u201d v\u00e0 \u201chi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7\u201d c\u1ee7a v\u1eafc xin.<\/p>\n

Theo quy \u0111\u1ecbnh c\u1ee7a T\u1ed5 ch\u1ee9c Y t\u1ebf th\u1ebf gi\u1edbi v\u00e0 c\u00e1c n\u01b0\u1edbc nh\u01b0 M\u1ef9, ch\u00e2u \u00c2u, Nh\u1eadt, H\u00e0n Qu\u1ed1c\u2026 v\u1eafc xin tr\u01b0\u1edbc khi \u0111\u01b0a v\u00e0o s\u1eed d\u1ee5ng kh\u1ea9n c\u1ea5p b\u1eaft bu\u1ed9c ph\u1ea3i th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi v\u1edbi 3 giai \u0111o\u1ea1n, trong \u0111\u00f3 giai \u0111o\u1ea1n 3 l\u00e0 giai \u0111o\u1ea1n quan tr\u1ecdng nh\u1ea5t.<\/p>\n

Giai \u0111o\u1ea1n n\u00e0y \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean quy m\u00f4 l\u1edbn v\u1edbi m\u1ee5c ti\u00eau \u0111\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 \u201chi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7\u201d c\u1ee7a v\u1eafc xin. K\u1ebft qu\u1ea3 c\u1ee7a giai \u0111o\u1ea1n 3 s\u1ebd quy\u1ebft \u0111\u1ecbnh vi\u1ec7c v\u1eafc xin \u0111\u00f3 c\u00f3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u0111\u1ec3 tri\u1ec3n khai ti\u00eam ch\u1ee7ng r\u1ed9ng r\u00e3i hay kh\u00f4ng. K\u1ec3 c\u1ea3 sau khi \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t, c\u00e1c lo\u1ea1i v\u1eafc xin \u0111\u00f3 \u0111\u1ec1u ph\u1ea3i li\u00ean t\u1ee5c b\u1ed5 sung, c\u1eadp nh\u1eadt c\u00e1c th\u00f4ng tin, d\u1eef li\u1ec7u li\u00ean quan \u0111\u1ebfn t\u00ednh an to\u00e0n, hi\u1ec7u qu\u1ea3 c\u1ee7a v\u1eafc xin trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng.<\/p>\n

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Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 1 v\u00e0 2 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u1edf quy m\u00f4 nh\u1ecf tr\u00ean m\u1ed9t s\u1ed1 nh\u00f3m qu\u1ea7n th\u1ec3 \u0111\u1ec3 ki\u1ec3m tra \u0111\u1ed9 an to\u00e0n, t\u00ednh sinh mi\u1ec5n d\u1ecbch v\u00e0 x\u00e1c \u0111\u1ecbnh li\u1ec1u l\u01b0\u1ee3ng t\u1ed1i \u01b0u. Vi\u1ec7c \u0111\u00e1nh gi\u00e1 \u201ct\u00ednh sinh mi\u1ec5n d\u1ecbch\u201d trong giai \u0111o\u1ea1n 1 v\u00e0 2 n\u00e0y kh\u00f4ng ph\u1ea3i l\u00e0 y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh cho vi\u1ec7c ph\u00ea duy\u1ec7t kh\u1ea9n c\u1ea5p.<\/p>\n

Ch\u1ec9 c\u00f3 k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 3 m\u1edbi l\u00e0 y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 v\u1eafc xin n\u00e0y c\u00f3 “hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7” hay kh\u00f4ng, c\u00f3 l\u00e0m gi\u1ea3m nguy c\u01a1 m\u1eafc COVID-19 hay kh\u00f4ng ho\u1eb7c gi\u1ea3m nh\u1eb9 t\u00ecnh tr\u1ea1ng b\u1ec7nh hay kh\u00f4ng.<\/p>\n

V\u1eady kh\u00e1i ni\u1ec7m \u201ct\u00ednh sinh mi\u1ec5n d\u1ecbch\u201d v\u00e0 \u201chi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7\u201d c\u1ee7a v\u1eafc xin l\u00e0 g\u00ec? PGS.TS .BS Ph\u1ea1m Th\u1ecb V\u00e2n Anh- Gi\u00e1m \u0111\u1ed1c Trung t\u00e2m D\u01b0\u1ee3c l\u00fd l\u00e2m s\u00e0ng, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Y H\u00e0 N\u1ed9i \u0111\u00e3 gi\u1ea3i \u0111\u00e1p xung quanh nh\u1eefng n\u1ed9i dung \u0111ang \u0111\u01b0\u1ee3c b\u1ea1n \u0111\u1ecdc quan t\u00e2m n\u00e0y.<\/p>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a v\u1eafc xin COVID-19<\/strong><\/p>\n

Theo PGS.TS.BS Ph\u1ea1m Th\u1ecb V\u00e2n Anh, sau khi v\u00e0o c\u01a1 th\u1ec3, v\u1eafc xin s\u1ebd mang m\u00e3 di truy\u1ec1n c\u1ee7a virus corona quy \u0111\u1ecbnh protein S cho t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean. T\u1eeb \u0111\u00f3, c\u01a1 th\u1ec3 b\u1eaft \u0111\u1ea7u h\u00ecnh th\u00e0nh c\u01a1 ch\u1ebf t\u1ef1 t\u1ea1o ra protein S.<\/p>\n

C\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch trong m\u00e1u nh\u1eadn di\u1ec7n protein S l\u00e0 \u201ck\u1ebb x\u00e2m nh\u1eadp\u201d, v\u00e0 \u0111i\u1ec1u n\u00e0y k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch.<\/p>\n

C\u01a1 th\u1ec3 b\u1eaft \u0111\u1ea7u t\u1ea1o ra kh\u00e1ng th\u1ec3 d\u1ecbch th\u1ec3 (IgG) v\u00e0 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch nh\u1eafm t\u1edbi m\u1ee5c ti\u00eau ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o c\u00f3 mang protein S. H\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch sau \u0111\u00f3 ti\u1ebfp t\u1ee5c t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o tr\u00ed nh\u1edb. Nh\u1eefng t\u1ebf b\u00e0o tr\u00ed nh\u1edb n\u00e0y c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n ra virus corona trong nh\u1eefng l\u1ea7n x\u00e2m nh\u1eadp sau b\u1eb1ng c\u00e1ch nh\u1eadn ra protein S tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a virus corona.<\/p>\n

\u201cN\u1ebfu c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch ph\u00e1t hi\u1ec7n ra virus corona trong c\u01a1 th\u1ec3, t\u1ebf b\u00e0o B s\u1ebd bi\u1ec7t h\u00f3a th\u00e0nh t\u01b0\u01a1ng b\u00e0o s\u1ea3n xu\u1ea5t c\u00e1c kh\u00e1ng th\u1ec3 d\u1ecbch th\u1ec3 v\u00e0 s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o T r\u1ea5t nhanh. \u0110i\u1ec1u n\u00e0y ng\u0103n ch\u1eb7n virus corona l\u00e2y lan v\u00e0 l\u00e0m gi\u1ea3m t\u00e1c h\u1ea1i do b\u1ec7nh COVID-19 g\u00e2y ra\u201d- Gi\u00e1m \u0111\u1ed1c Trung t\u00e2m d\u01b0\u1ee3c l\u00fd l\u00e2m s\u00e0ng, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Y H\u00e0 N\u1ed9i n\u00eau r\u00f5.<\/p>\n

T\u00ednh sinh mi\u1ec5n d\u1ecbch (immunogenicity) c\u1ee7a v\u1eafc xin l\u00e0 g\u00ec?<\/strong><\/p>\n

\u201cT\u00ednh sinh mi\u1ec5n d\u1ecbch c\u1ee7a v\u1eafc xin l\u00e0 g\u00ec? \u0110\u00f3 l\u00e0 kh\u1ea3 n\u0103ng k\u00edch th\u00edch c\u01a1 th\u1ec3 sinh ra \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3 ho\u1eb7c \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o \u0111\u1eb7c hi\u1ec7u v\u1edbi kh\u00e1ng nguy\u00ean\u201d- PGS.TS.BS V\u00e2n Anh l\u00fd gi\u1ea3i.<\/p>\n

Theo \u0111\u00f3, t\u1ebf b\u00e0o B + kh\u00e1ng nguy\u00ean, \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3.<\/p>\n

T\u1ebf b\u00e0o T + kh\u00e1ng nguy\u00ea, \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o.<\/p>\n

\u201cV\u1edbi \u00fd ngh\u0129a n\u00e0y ch\u00fang ta c\u00f3 th\u1ec3 g\u1ecdi c\u00e1c kh\u00e1ng nguy\u00ean d\u01b0\u1edbi m\u1ed9t t\u00ean kh\u00e1c ch\u00ednh x\u00e1c h\u01a1n l\u00e0 ch\u1ea5t sinh mi\u1ec5n d\u1ecbch (immunogen). V\u1eafc xin ch\u00ednh l\u00e0 c\u00e1c ch\u1ea5t sinh mi\u1ec5n d\u1ecbch. M\u1ed9t v\u1eafc xin b\u1eaft bu\u1ed9c ph\u1ea3i c\u00f3 \u201ct\u00ednh sinh mi\u1ec5n d\u1ecbch\u201d- PGS.TS.BS Ph\u1ea1m Th\u1ecb V\u00e2n Anh n\u00f3i.<\/p>\n

Sau khi ti\u00eam v\u1eafc xin m\u1ed9t th\u1eddi gian nh\u1ea5t \u0111\u1ecbnh (th\u01b0\u1eddng \u0111\u00e1nh gi\u00e1 sau khi ti\u00eam m\u0169i 2 kho\u1ea3ng 14 ng\u00e0y) c\u01a1 th\u1ec3 s\u1ebd sinh ra kh\u00e1ng th\u1ec3 d\u1ecbch th\u1ec3 kh\u00e1ng protein S c\u1ee7a virus corona, \u0111\u1ed3ng th\u1eddi sinh ra c\u1ea3 c\u00e1c \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch qua trung gian t\u1ebf b\u00e0o.<\/p>\n

Tuy nhi\u00ean, PGS.TS.BS Ph\u1ea1m Th\u1ecb V\u00e2n Anh c\u0169ng cho hay, trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p m\u1ed9t v\u1eafc xin c\u00f3 \u201ct\u00ednh sinh mi\u1ec5n d\u1ecbch\u201d ch\u01b0a ch\u1eafc \u0111\u00e3 c\u00f3 \u201chi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7\u201d.<\/strong><\/em><\/p>\n

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Ti\u00eam v\u1eafc xin ph\u00f2ng COVID-19 cho ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n tham gia th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 3 t\u1ea1i H\u1ecdc vi\u1ec7n Qu\u00e2n Y. (\u1ea2nh mang t\u00ednh ch\u1ea5t minh ho\u1ea1)<\/em><\/p>\n

V\u00ec v\u1eady c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng th\u1eed nghi\u1ec7m v\u1eafc xin th\u01b0\u1eddng b\u1eaft bu\u1ed9c ph\u1ea3i \u0111\u00e1nh gi\u00e1 “hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7”. V\u1edbi v\u1eafc xin COVID-19, t\u1ea1i th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i T\u1ed5 ch\u1ee9c Y t\u1ebf th\u1ebf gi\u1edbi y\u00eau c\u1ea7u ph\u1ea3i \u0111\u00e1nh gi\u00e1 c\u1ea3 \u201ct\u00ednh sinh mi\u1ec5n d\u1ecbch\u201d v\u00e0 \u201chi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7\u201d c\u1ee7a v\u1eafc xin.<\/p>\n

Hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7 c\u1ee7a v\u1eafc xin (effective of vaccine) l\u00e0 g\u00ec?<\/strong><\/p>\n

Vi\u1ec7c \u0111o l\u01b0\u1eddng kh\u1ea3 n\u0103ng b\u1ea3o v\u1ec7 c\u1ee7a v\u1eafc xin ch\u1ed1ng l\u1ea1i b\u1ec7nh trong qu\u00e1 tr\u00ecnh th\u1eed nghi\u1ec7m (th\u01b0\u1eddng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 th\u00f4ng qua th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha 3).<\/p>\n

Theo T\u1ed5 ch\u1ee9c Y t\u1ebf th\u1ebf gi\u1edbi “hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7” c\u1ee7a v\u1eafc xin ph\u1ea3i \u0111\u1ea1t t\u1ed1i thi\u1ec3u 50%.<\/p>\n

V\u1eafc xin COVID-19 hi\u1ec7u qu\u1ea3 nh\u01b0 th\u1ebf n\u00e0o?<\/strong><\/p>\n

Theo PGS.TS.BS Ph\u1ea1m Th\u1ecb V\u00e2n Anh, hi\u1ec7n c\u00f3 nhi\u1ec1u lo\u1ea1i v\u1eafc xin COVID-19 \u0111ang trong c\u00e1c giai \u0111o\u1ea1n kh\u00e1c nhau c\u1ee7a qu\u00e1 tr\u00ecnh th\u1eed nghi\u1ec7m, ph\u00ea duy\u1ec7t v\u00e0 ph\u00e2n ph\u1ed1i.<\/p>\n

C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho th\u1ea5y v\u1eafc xin c\u1ee7a Pfizer c\u00f3 hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7 l\u00e0 95% v\u00e0 v\u1eafc xin Moderna c\u00f3 hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7 l\u00e0 94% trong vi\u1ec7c ng\u0103n ch\u1eb7n b\u1ec7nh COVID-19 c\u00f3 tri\u1ec7u ch\u1ee9ng.<\/p>\n

\u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 t\u1ef7 l\u1ec7 m\u1eafc COVID-19 \u1edf nh\u1eefng ng\u01b0\u1eddi tham gia ti\u00eam v\u1eafc xin ch\u1ec9 b\u1eb1ng 5- 6% t\u1ef7 l\u1ec7 m\u1eafc \u1edf nh\u1eefng ng\u01b0\u1eddi s\u1eed d\u1ee5ng gi\u1ea3 d\u01b0\u1ee3c. Nh\u01b0 v\u1eady v\u1eabn c\u00f3 kh\u1ea3 n\u0103ng nh\u1ecf b\u1ecb l\u00e2y nhi\u1ec5m b\u1ec7nh sau khi ti\u00eam v\u1eafc xin.<\/p>\n

Ngu\u1ed3n B\u1ed9 Y t\u1ebf<\/em><\/strong><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p m\u1ed9t v\u1eafc xin c\u00f3 \u201ct\u00ednh sinh mi\u1ec5n d\u1ecbch\u201d ch\u01b0a ch\u1eafc \u0111\u00e3 c\u00f3 \u201chi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7\u201d. V\u00ec v\u1eady c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng th\u1eed nghi\u1ec7m v\u1eafc xin th\u01b0\u1eddng b\u1eaft bu\u1ed9c ph\u1ea3i \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 b\u1ea3o v\u1ec7. V\u1edbi v\u1eafc xin COVID-19, t\u1ea1i th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i T\u1ed5 ch\u1ee9c Y t\u1ebf […]<\/p>\n","protected":false},"author":3,"featured_media":5980,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","footnotes":""},"categories":[235],"tags":[],"class_list":["post-5979","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phong-chong-covid-19"],"_links":{"self":[{"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/posts\/5979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/comments?post=5979"}],"version-history":[{"count":2,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/posts\/5979\/revisions"}],"predecessor-version":[{"id":5983,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/posts\/5979\/revisions\/5983"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/media\/5980"}],"wp:attachment":[{"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/media?parent=5979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/categories?post=5979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/tags?post=5979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}