{"id":12835,"date":"2022-02-21T20:25:52","date_gmt":"2022-02-21T13:25:52","guid":{"rendered":"https:\/\/cdcangiang.vn\/?p=12835"},"modified":"2022-02-21T20:25:52","modified_gmt":"2022-02-21T13:25:52","slug":"nhung-doi-tuong-nao-khong-duoc-dung-molnupiravir-trong-chua-tri-covid-19","status":"publish","type":"post","link":"https:\/\/cdcangiang.vn\/index.php\/2022\/02\/21\/nhung-doi-tuong-nao-khong-duoc-dung-molnupiravir-trong-chua-tri-covid-19\/","title":{"rendered":"Nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0o kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng Molnupiravir trong ch\u1eefa tr\u1ecb COVID-19?"},"content":{"rendered":"

Thu\u1ed1c Molnupiravir l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i thu\u1ed1c kh\u00e1ng virus \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf \u0111\u01b0a v\u00e0o ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb COVID-19 \u1edf Vi\u1ec7t Nam. Thu\u1ed1c gi\u00fap ng\u01b0\u1eddi m\u1eafc COVID-19 m\u1ee9c \u0111\u1ed9 nh\u1eb9 v\u00e0 v\u1eeba c\u00f3 th\u00eam c\u01a1 h\u1ed9i l\u1ef1a ch\u1ecdn thu\u1ed1c \u0111i\u1ec1u tr\u1ecb. Tuy nhi\u00ean, nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0o kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng Molnupiravir trong ch\u1eefa tr\u1ecb COVID-19?<\/h2>\n
\n

M\u1edbi \u0111\u00e2y, C\u1ee5c Qu\u1ea3n l\u00fd D\u01b0\u1ee3c, B\u1ed9 Y t\u1ebf c\u00f3 quy\u1ebft \u0111\u1ecbnh c\u1ea5p s\u1ed1 \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh cho 3 thu\u1ed1c ch\u1ee9a ho\u1ea1t ch\u1ea5t Molnupiravir s\u1ea3n xu\u1ea5t trong n\u01b0\u1edbc l\u00e0: Molravir 400 c\u1ee7a C\u00f4ng ty CP D\u01b0\u1ee3c ph\u1ea9m Boston Vi\u1ec7t Nam, Movinavir c\u1ee7a C\u00f4ng ty CP h\u00f3a-d\u01b0\u1ee3c ph\u1ea9m Mekorpha v\u00e0 Molnupiravir Stella 400mg c\u1ee7a C\u00f4ng ty TNHH Li\u00ean doanh Stellapharm. Thu\u1ed1c Molnupiravir gi\u00fap ng\u01b0\u1eddi m\u1eafc COVID-19 m\u1ee9c \u0111\u1ed9 nh\u1eb9 v\u00e0 v\u1eeba c\u00f3 th\u00eam c\u01a1 h\u1ed9i l\u1ef1a ch\u1ecdn thu\u1ed1c \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Theo Ths. Nguy\u1ec5n Qu\u1ed1c Th\u00e1i – Chuy\u00ean gia b\u1ec7nh truy\u1ec1n nhi\u1ec5m (B\u1ec7nh vi\u1ec7n B\u1ea1ch Mai, H\u00e0 N\u1ed9i), Molnupiravir \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb COVID-19 m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh d\u01b0\u01a1ng t\u00ednh v\u1edbi x\u00e9t nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n SARS-CoV-2 v\u00e0 c\u00f3 \u00edt nh\u1ea5t m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1 l\u00e0m b\u1ec7nh ti\u1ebfn tri\u1ec3n n\u1eb7ng. Molnupiravir d\u00f9ng tr\u00ean b\u1ec7nh nh\u00e2n c\u00f3 th\u1eddi gian kh\u1edfi ph\u00e1t tri\u1ec7u ch\u1ee9ng d\u01b0\u1edbi 5 ng\u00e0y; kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng qu\u00e1 5 ng\u00e0y li\u00ean ti\u1ebfp v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 d\u1ef1 ph\u00f2ng sau hay tr\u01b0\u1edbc ph\u01a1i nhi\u1ec5m \u0111\u1ec3 ph\u00f2ng COVID-19.<\/p>\n

\n
\"Zalo\"
Thu\u1ed1c Molnupiravir c\u00f3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb COVID-19 th\u1ec3 nh\u1eb9 v\u00e0 trung b\u00ecnh.<\/figcaption><\/figure>\n<\/div>\n

Theo Ths. Nguy\u1ec5n Qu\u1ed1c Th\u00e1i, thu\u1ed1c Molnupiravir c\u00f3 c\u01a1 ch\u1ebf g\u00e2y \u0111\u1ed9t bi\u1ebfn, l\u00e0m gi\u00e1n \u0111o\u1ea1n sao ch\u00e9p RNA d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf s\u1ef1 nh\u00e2n l\u00ean c\u1ee7a virus. Vi\u1ec7c s\u1eed d\u1ee5ng Monulpiravia \u0111\u01b0\u1ee3c quy \u0111\u1ecbnh r\u1ea5t ch\u1eb7t ch\u1ebd, c\u00f3 nhi\u1ec1u \u0111\u1ed1i t\u01b0\u1ee3ng kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ho\u1eb7c s\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng lo\u1ea1i thu\u1ed1c n\u00e0y trong \u0111i\u1ec1u tr\u1ecb COVID-19.<\/p>\n

Thu\u1ed1c Molnupiravir l\u00e0 thu\u1ed1c kh\u00e1ng virus SARS-CoV-2 do H\u00e3ng d\u01b0\u1ee3c Merck & Co. (M\u1ef9) nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n. K\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho th\u1ea5y, thu\u1ed1c kh\u00e1ng virus Molnupiravir cho k\u1ebft qu\u1ea3 kh\u1ea3 quan v\u1ec1 t\u00ednh an to\u00e0n, l\u00e0m s\u1ea1ch virus SARS-CoV-2 \u1edf b\u1ec7nh nh\u00e2n COVID-19 th\u1ec3 nh\u1eb9 v\u00e0 v\u1eeba sau 5 ng\u00e0y \u0111i\u1ec1u tr\u1ecb, gi\u1ea3m t\u1ef7 l\u1ec7 nh\u1eadp vi\u1ec7n, gi\u1ea3m t\u1eed vong.<\/p>\n

Thu\u1ed1c Molnupiravir thu\u1ed9c nh\u00f3m thu\u1ed1c kh\u00e1ng virus mang t\u00ean “ch\u1ea5t \u1ee9c ch\u1ebf polymerase”, ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch t\u1ea5n c\u00f4ng v\u00e0o m\u1ed9t lo\u1ea1i enzym m\u00e0 virus d\u00f9ng \u0111\u1ec3 sao ch\u00e9p v\u1eadt li\u1ec7u di truy\u1ec1n r\u1ed3i \u0111\u01b0a v\u00e0o \u0111\u00f3 c\u00e1c \u0111\u1ed9t bi\u1ebfn khi\u1ebfn virus kh\u00f4ng th\u1ec3 t\u00e1i t\u1ea1o. V\u00ec kh\u00e1ng th\u1ec3 t\u1ea5n c\u00f4ng protein b\u1ec1 m\u1eb7t c\u1ee7a virus SARS-CoV-2 li\u00ean t\u1ee5c ti\u1ebfn h\u00f3a, n\u00ean thu\u1ed1c kh\u00e1ng virus \u0111\u01b0\u1ee3c tr\u00f4ng \u0111\u1ee3i s\u1ebd ch\u1ed1ng l\u1ea1i \u0111\u01b0\u1ee3c nhi\u1ec1u bi\u1ebfn th\u1ec3 h\u01a1n.<\/p>\n

Theo k\u1ebft qu\u1ea3 qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u, khi virus x\u00e2m nh\u1eadp t\u1ebf b\u00e0o, n\u00f3 gi\u1ea3i ph\u00f3ng ARN nh\u1eb1m nh\u00e2n b\u1ea3n ch\u00ednh n\u00f3 r\u1ed3i ti\u1ebfp t\u1ee5c l\u00e2y nhi\u1ec5m c\u00e1c t\u1ebf b\u00e0o kh\u00e1c. Thu\u1ed1c kh\u00e1ng virus Molnupiravir c\u00f3 ch\u1ee9c n\u0103ng g\u00e2y r\u1ed1i qu\u00e1 tr\u00ecnh sao ch\u00e9p c\u1ee7a virus b\u1eb1ng c\u00e1ch ch\u00e8n l\u1ed7i v\u00e0o ARN virus \u0111\u1ec3 virus kh\u00f4ng th\u1ec3 t\u1ea1o ra c\u00e1c h\u1ea1t virus l\u00e2y nhi\u1ec5m.<\/p>\n

Vi\u1ec7c B\u1ed9 Y t\u1ebf c\u1ea5p ph\u00e9p 3 thu\u1ed1c ch\u1ee9a ho\u1ea1t ch\u1ea5t Molnupiravir s\u1ea3n xu\u1ea5t trong n\u01b0\u1edbc \u0111\u01b0\u1ee3c c\u1ea5p gi\u1ea5y ph\u00e9p l\u01b0u h\u00e0nh trong th\u1eddi h\u1ea1n 3 n\u0103m \u0111\u00e3 gi\u00fap ng\u01b0\u1eddi m\u1eafc COVID-19 m\u1ee9c \u0111\u1ed9 nh\u1eb9 v\u00e0 v\u1eeba c\u00f3 th\u00eam c\u01a1 h\u1ed9i l\u1ef1a ch\u1ecdn thu\u1ed1c \u0111i\u1ec1u tr\u1ecb. Tuy nhi\u00ean, nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0o khuy\u1ebfn c\u00e1o kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng Molnupiravir trong ch\u1eefa tr\u1ecb COVID-19?<\/p>\n

Tr\u01b0\u1edbc khi c\u1ea5p ph\u00e9p cho Molnupiravir t\u1ea1i Vi\u1ec7t Nam, c\u00e1c th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng t\u01b0 v\u1ea5n c\u1ea5p gi\u1ea5y \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh thu\u1ed1c (B\u1ed9 Y t\u1ebf) \u0111\u00e3 th\u1ed1ng nh\u1ea5t v\u1ec1 c\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c.<\/p>\n

\n
\"Zalo\"
Thai ph\u1ee5 \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c Molnupiravir trong th\u1eddi k\u1ef3 mang thai. \u1ea2nh minh h\u1ecda<\/figcaption><\/figure>\n<\/div>\n

\u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n

Molnupiravir kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng trong th\u1eddi k\u1ef3 mang thai. Ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai n\u00ean s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u00e0 trong 4 ng\u00e0y sau li\u1ec1u Molnupiravir cu\u1ed1i c\u00f9ng;<\/p>\n

D\u1ef1a tr\u00ean kh\u1ea3 n\u0103ng x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i cho tr\u1ebb s\u01a1 sinh t\u1eeb Molnupiravir, kh\u00f4ng khuy\u1ebfn c\u00e1o cho con b\u00fa trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u00e0 trong 4 ng\u00e0y sau li\u1ec1u Molnupiravir cu\u1ed1i c\u00f9ng.<\/p>\n

\u0110\u1ed1i v\u1edbi tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean:<\/strong><\/p>\n

Molnupiravir kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e9p s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 18 tu\u1ed5i v\u00ec c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a x\u01b0\u01a1ng v\u00e0 s\u1ee5n.<\/p>\n

\u0110\u1ed1i v\u1edbi nam gi\u1edbi:<\/strong><\/p>\n

Molnupiravir c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tinh tr\u00f9ng, m\u1eb7c d\u00f9 r\u1ee7i ro \u0111\u01b0\u1ee3c coi l\u00e0 th\u1ea5p. V\u00ec v\u1eady, nam gi\u1edbi ho\u1ea1t \u0111\u1ed9ng t\u00ecnh d\u1ee5c v\u1edbi ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng sinh \u0111\u1ebb n\u00ean s\u1eed d\u1ee5ng m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p tr\u00e1nh thai tin c\u1eady trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u00e0 \u00edt nh\u1ea5t 3 th\u00e1ng sau li\u1ec1u Molnupiravir cu\u1ed1i c\u00f9ng.<\/p>\n

Ngo\u00e0i ra, ng\u01b0\u1eddi b\u1ecb suy gan, suy th\u1eadn c\u00f3 th\u1ec3 u\u1ed1ng Monulpiravir, nh\u01b0ng c\u1ea7n d\u00f9ng m\u1ed9t c\u00e1ch th\u1eadn tr\u1ecdng. B\u00ean c\u1ea1nh \u0111\u00f3, c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p c\u1ee7a Molnupiravir l\u00e0 ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, ch\u00f3ng m\u1eb7t, t\u0103ng men gan…<\/p>\n

\u0110\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n, hi\u1ec7u qu\u1ea3, ch\u1ec9 s\u1eed d\u1ee5ng thu\u1ed1c Molnupiravir \u0111i\u1ec1u tr\u1ecb COVID-19 khi c\u00f3 \u0111\u01a1n c\u1ee7a b\u00e1c s\u0129 theo \u0111\u00fang ch\u1ec9 \u0111\u1ecbnh, c\u00e1c gi\u1edbi h\u1ea1n s\u1eed d\u1ee5ng v\u00e0 c\u00e1c c\u1ea3nh b\u00e1o, th\u1eadn tr\u1ecdng c\u1ee7a thu\u1ed1c. Kh\u00f4ng t\u1ef1 \u00fd mua, s\u1eed d\u1ee5ng thu\u1ed1c Molnupiravir tr\u00f4i n\u1ed5i, kh\u00f4ng r\u00f5 ngu\u1ed3n g\u1ed1c, xu\u1ea5t x\u1ee9 tr\u00ean th\u1ecb tr\u01b0\u1eddng. Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c Molnupiravir, n\u1ebfu g\u1eb7p ph\u1ea3i b\u1ea5t k\u1ef3 ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i n\u00e0o c\u1ee7a thu\u1ed1c, c\u1ea7n th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u1ef9 ho\u1eb7c d\u01b0\u1ee3c s\u1ef9 \u0111\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n v\u00e0 x\u1eed tr\u00ed k\u1ecbp th\u1eddi.<\/p>\n

B\u1ed9 Y t\u1ebf.<\/strong><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Thu\u1ed1c Molnupiravir l\u00e0 m\u1ed9t trong nh\u1eefng lo\u1ea1i thu\u1ed1c kh\u00e1ng virus \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf \u0111\u01b0a v\u00e0o ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb COVID-19 \u1edf Vi\u1ec7t Nam. Thu\u1ed1c gi\u00fap ng\u01b0\u1eddi m\u1eafc COVID-19 m\u1ee9c \u0111\u1ed9 nh\u1eb9 v\u00e0 v\u1eeba c\u00f3 th\u00eam c\u01a1 h\u1ed9i l\u1ef1a ch\u1ecdn thu\u1ed1c \u0111i\u1ec1u tr\u1ecb. Tuy nhi\u00ean, nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0o kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng Molnupiravir trong ch\u1eefa […]<\/p>\n","protected":false},"author":4,"featured_media":11350,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","footnotes":""},"categories":[241,235],"tags":[],"class_list":["post-12835","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cap-nhat-tin-covid","category-phong-chong-covid-19"],"_links":{"self":[{"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/posts\/12835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/comments?post=12835"}],"version-history":[{"count":0,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/posts\/12835\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/media\/11350"}],"wp:attachment":[{"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/media?parent=12835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/categories?post=12835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cdcangiang.vn\/index.php\/wp-json\/wp\/v2\/tags?post=12835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}